James J. Fabrizio, Ph.D.
Areas of Interest
- Drosophila genetics
- Molecular Biology
Dr. Fabrizio’s lab seeks to uncover genes involved in the late-stage maturation of spermatozoa in Drosophila. Specifically, since sperm in all animal species occurs within a common cytoplasm, all animals have to resolve individual sperm from this cytoplasm in a process known as spermatid individualization. Indeed, a failure to individualize sperm is the predominant cause of male infertility in humans. Given the genetic similarity (65-70 percent) between Drosophila and humans, we hope our work will shed some light on the molecular mechanisms behind human male fertility.
Dr. Fabrizio received a National Institutes of Health grant for $200,000 as principal investigator. He will be incorporating methods and knowledge of genetics, molecular biology, cell biology, and genomics to study sperm development in the fruit fly, or Drosophila melanogaster.
- BIOL 111 General Biology
- BIOL 310/410 Research in Biology
- BIOL 321 Molecular Biology
- BIOL 302 Developmental Biology
- BIOL 217 Genetics
- BIOL 331 Cell Biology
Fabrizio, J. J., Aqeel, N., Cote, J., Estevez, J., Jongoy, M., Mangal, V., Tema, W., Rivera, A., Wnukowski, J., and Bencosme, Y., “mulet (mlt) encodes a tubulin-binding cofactor E-like homolog required for spermatid individualization in Drosophila melanogaster,” Fly 6:4, 261-272, 2012
Fabrizio, J. J., Hickey, C. A., Stabrawa, C., Meytes, V., Hutter, J.A., Talbert, C., and Regis, N., “Imp (IGF-II mRNA binding protein) is expressed during spermatogenesis in Drosophila melanogaster,” Fly 2:1, 47-52, 2008
Fabrizio, J. J., Boyle, M., and DiNardo, S., “A somatic role for eyes absent (eya) and sine oculis (so) in Drosophila spermatocyte development,” Developmental Biology 258: 117–28, 2003
Fabrizio, J. J., Hime, G., Lemmon, S. K., and Bazinet, C., “Genetic dissection of sperm individualization in Drosophila melanogaster,” Development 125: 1833–43, 1998